Modified Mitochondrial Transplantation

The Power of Mitochondria

Often called the “powerhouse of the cell,” mitochondria play a central role in energy production, cellular metabolism, and the regulation of cell life and death. Their dysfunction is directly linked to a wide range of diseases—from neurodegeneration to cancer.

Mitochondria is Essential for Cells

Beyond energy generation, mitochondria are key players in calcium signaling, apoptosis, and immune responses. Their health determines how cells adapt, survive, and function—making them central to our therapeutic strategies.

🔋 Source of Energy

Mitochondria generate over 90% of a cell’s energy through ATP production.

🧠 Signaling Pathway

They regulate cell fate via calcium homeostasis and redox signaling.

🧬 Cell Survival & Death

Mitochondria control apoptosis, which is crucial for tissue health.

🛡️ Immunity & Inflammation

They influence innate immunity and inflammatory responses.

Mitochondria Dysfunction
Root of Many Diseases

When mitochondria fail to function properly, the consequences at the cellular level are profound. Cells begin to lose their capacity to produce sufficient energy (ATP), leading to impaired function and survival. Dysfunctional mitochondria also generate excessive reactive oxygen species (ROS) and accumulate toxic metabolic byproducts, which damage cellular components and DNA. This cascade of cellular stress can activate harmful signaling pathways, inflammation, and eventually lead to programmed cell death (apoptosis).

Mitochondrial dysfunction has been increasingly recognized as a fundamental driver of numerous diseases. These include neurodegenerative disorders such as Parkinson’s and Alzheimer’s, metabolic conditions like diabetes and obesity, as well as cardiovascular diseases and accelerated aging. Understanding and correcting mitochondrial dysfunction is key to addressing these complex, chronic illnesses at their root cause.

Importance of Maintaining
Mitochondria Healthy

Healthy mitochondria ensure the balance of cellular homeostasis. Interventions that preserve or restore mitochondrial function are critical for preventing chronic diseases and improving overall cellular health.

When properly maintained, mitochondria support energy production, protect against oxidative stress, and enhance the cell’s resilience against aging and degeneration.

Address Diseases with
PAEAN’s Mitochondria-
based Technology

PAEAN is developing mitochondria-based technologies which offer potential therapeutic avenues for a wide range of diseases, from rare disease like Polymyositis/Dermatomyositis to mitochondrial dysfunction related diseases like neurodegenerative diseases, cancer, etc.